NPPB and hydrops fetalis: The Prospective Comparison of ARNI with ARB Global Outcomes in HF With Preserved Ejection Fraction (PARAGON; NCT01920711) is a randomised, double-blind, event-driven trial comparing the efficacy and safety of valsartan vs sacubitril/valsartan in patients with HFpEF that has enrolled 4822 patients (mean age 73 ± 8 years, median NT-proBNP 911 (interquartile range 464–1610) pg/mL, > 2/3 in sinus rhythm) [30].