In the Comparison of Sacubitril–Valsartan versus Enalapril on Effect on NT-proBNP in Patients Stabilized from an Acute Heart Failure Episode (PIONEER-HF) trial, initiation of sacubitril/valsartan for patients with either new-onset or chronic HFrEF (n = 881) during the in-hospital recovery phase after an acute decompensation was as safe as initiating enalapril, but led to a greater, and earlier (within 1 week), reduction in plasma concentrations of NT-proBNP, which was sustained until the end of 8 weeks follow-up [27]. This evidence concerns the gene NPPB and hydrops fetalis.