No difference was found in a combined inflammatory index consisting of CRP, IL-6 and TNF-α in a study of 93 patients with GAD and comorbid ischaemic heart disease.41 One case-controlled study35 of 48 Chinese outpatients presenting for the first time with a diagnosis of GAD and 48 age-matched, sex-matched and education-matched controls accounted for all results for IL-1α, IL-5, IL-8 and IL-12p70. This evidence concerns the gene TNF and generalized anxiety disorder.