However, it is unclear whether these differences remain significant after adjustment for group differences and no associations were found between IL-6 and participants who had all types of anxiety disorder.36 Two studies35 45 (n=165), one of which used saliva samples,45 reported significantly higher IL-6 in medication-naïve participants with a diagnosis of GAD compared with age-matched and sex-matched healthy controls. Here, IL6 is linked to anxiety disorder.