CRP and major depressive disorder: Of the nine studies to analyse CRP, four (44.4%) did not exclude or adjust for medication use by participants.33 38 40 41 Comorbid MDD was not adjusted for in the analysis by two studies,39 41 one of which was included in the meta-analysis.39 Only three of the nine studies reported time of sample collection35 36 42 or whether this was in a fasted state,36 41 42 and although all studies used a similar assay method, different assay types were used in every study.