PRF1 and infection: With respect to the second question and the possible role of persistent spleen neutrophil accumulation as part of the infection‐associated immunopathology, it should be noted that a link between trypanosomosis‐associated B cell depletion and the activation of the NK‐perforin pathway has been suggested.30 Hence, since neutrophils can be an additional source of perforin, they could possibly contribute to B cell depletion during infection and aggravate the reported detrimental NK cell activity.