2018). The hypersensitivity tonegative feedback seen in unmedicated depression (Taylor Tavares et al.2008) was also present in depressedindividuals treated with SSRIs (Murphy et al. 2003), and PRL deficits in OCD persist despite SSRI use as well(Ersche et al. 2011; Hauser et al.2017; Remijnse et al. 2006). A possible explanation is that SSRIs donot modulate serotonergic activity in the OFC as readily as in other parts of thefrontal cortex (El Mansari et al. 1995), and OFC abnormalities are present in depression (Bremneret al. 2002), as well as inOCD. This evidence concerns the gene PRL and depressive disorder.