Simultaneous increase in both Hsp60 and Hsp10 expressions is also observed in various types of mammalian tissues and cells during pathological conditions, such as myocardial ischemia (Lau et al. 1997; Lin et al. 2001) or cancer (Cappello et al. 2003, 2008). The gene discussed is HSPD1; the disease is myocardial ischemia.