Patients carrying variants of unconfirmed pathogenicity and risk variants for Parkinson’s disease identified from exome sequencing are reported in Supplementary Table 4, including variants in GIGYF2, CHDCHD2. These variants were detected in cases, as previously described, but also almost all occur in the control population and were not included as pathogenic variants in our analysis. The gene discussed is GIGYF2; the disease is Parkinson disease.