To validate the link between CD58/CD2-dependent STAT1 phosphorylation and CD58/CD2-induced IFNγ production, we blocked STAT1 phosphorylation with fludarabine and analyzed IFNγ production in a coculture of IFNγ-pretreated KCs and naive T cells after 24 h. The gene discussed is CD2; the disease is dry eye syndrome.