TAT and pulmonary arterial hypertension: Here, we report the first integrated analysis of altered lncRNA, miRNA and mRNA expression in hyper-proliferative human primary PASMCs treated with cocaine and Tat uncovering the critical interactions between these molecules that may eventually help us not only in understanding the cocaine and Tat induced hyper-proliferation but also in general regulation of smooth muscle dysfunction associated with all types of pulmonary hypertension.