For boys, CLNK codes for a protein that plays a role in the regulation of immunoreceptor signaling, MAN1B1 encodes an enzyme belonging to the glycosyl hydrolase 47 family, which can cause autosomal-recessive intellectual disability when mutated, and ADAMTS17 codes for a member of the ADAMTS protein family which can remodel the extracellular matrix. The gene discussed is CLNK; the disease is intellectual disability, autosomal recessive.