We note also that the minor alleles of group I SNPs (represented by rs706778 and rs11256557 in the haplotype analysis, Supplementary Fig. 9) selected for RA-international are carried along with the minor protective alleles of groups A, C and D and it is possible that the group I SNPs are tagging three IL2RA SNP groups. This evidence concerns the gene IL2RA and rheumatoid arthritis.