These data combined with the fact that FGF2 efficiently reduces p53 expression levels while promoting the growth in PyMT-cancer cells (Supplementary Fig. 8a, b; refs. 31,49) lead us to propose that ZEB1 deletion in stromal CAFs stabilises p53 protein and thus decreases FGF2 production and secretion in the surrounding stroma (or conditioned medium). This evidence concerns the gene TP53 and cancer.