BCL2L1 and liver disorder: Hence, our structural and functional analyses of the HBx/Bcl-xL interaction not only identify key residues and the structural basis that mediate binding of HBx to Bcl-xL and a new and distinct binding pocket in Bcl-xL for the HBx-BH3-like motif but also point out the need to employ a new strategy to screen for unique HBx-BH3-like mimetics that can inhibit HBV replication and treat HBV-related liver disease.