CD8A and neoplasm: HMGB1 was found to be critical for β-lap-induced immunogenicity in three experiments: (i) BMDCs were exposed to OVA protein for 4 h, then naïve OT1 CD8+ T cells and the supernatants from β-lap-treated tumor cells (with/without αHMGB1 antibody or knockdown the HMGB1 in MC38 cells).