It has been previously reported that in colon cancer cells ETAR triggers YAP/TAZ activation through Gαq/1127, and in OC cells lysophosphatidic acid (LPA) receptor induced G12/13/Rho/YAP pathway28, implying that regulation of YAP/TAZ pathway by GPCR is functionally and structurally centered on G-protein-dependent pathway. This evidence concerns the gene WWTR1 and malignant colon neoplasm.