To gain insight into the molecular mechanisms associated with PO effects of Cyfip1 deletion on PF intake, we examined transcription of Cyfip1, Cyfip2, and Magel2 - a nearby imprinted gene within the syntenic, canonical PWS region that is implicated in hyperphagia and obesity (Tacer and Potts. This evidence concerns the gene CYFIP1 and obesity due to melanocortin 4 receptor deficiency.