Concerning the molecular mechanisms, it has been suggested the role of osteopontin, a glycoprotein involved in cell adhesion and extracellular matrix remodeling, that regulates the migration of melanoma cells to the bone marrow niche [26, 27], while the high-expression of leukaemia inhibitory factor (LIF) has been recently associated with malignant osteolysis by the TGF-β pathway activation [28]. The gene discussed is SPP1; the disease is melanoma.