WNT5B and neoplasm: This points to enhanced Wnt signaling within the CSC compartment upon co-culture with alternatively activated M2-like macrophages, likely mediated by secreted Wnt (specifically also WNT5B) arising from the macrophage compartment, in line with several observations where tumor associated/M2 macrophages increase Wnt signaling in epithelial cells [22, 47–49].