As demonstrated in Fig. 10a-d, the in vivo tumor formation assay suggested that hsa_circ_0058124 knockdown dramatically inhibited tumor growth when compared to the negative control group, whereas suppression of NOTCH3 or GATAD2A partly abolished this reduction of tumor growth by hsa_circ_0058124 knockdown. The gene discussed is GATAD2A; the disease is neoplasm.