However, for SNPs previously reported to be associated with COPD and spirometric measures of lung function, the variant in the DSP gene, rs2076295, was associated with the annual change in %LAA-950 (risk allele = T, β (SE) =0.09 (0.02), P = 3.79e-05) (Table 2). Here, DSP is linked to chronic obstructive pulmonary disease.