In accordance, our results in this report revealed that HCC patients with HBsAg showed a significantly stronger overexpression of Pin1 and RhoC, and similar trend for RhoA, in HCC when compared to adjacent normal liver (Additional file 3: Figure S1), though the effect of HBV proteins on their transcription has not been demonstrated yet. The gene discussed is RHOA; the disease is hepatocellular carcinoma.