We also examined the potential interaction between Pin1 and two members of the Rho subfamily of the Ras superfamily of homologious genes, RhoA and RhoC, which has been implicated in tumorigenesis, tumor progression and metastasis of HCC [11–15] by determining the clinical correlation of their expressions individually and in combination with HCC prognosis. The gene discussed is PIN1; the disease is hepatocellular carcinoma.