Hence, our results clearly demonstrated the correlations of Pin1 with RhoA and RhoC as well as their involvement in the metastatic process, and their co-overexpressions associated with metastatic HCC, which further potentiates the development of combined inhibitors against Pin1/RhoA/RhoC in order to combat metastasis in HCC patients. The gene discussed is PIN1; the disease is hepatocellular carcinoma.