Nevertheless, it is unknown whether anti-apoA-I IgGs provide incremental prognostic value over the Global Registry of Acute Coronary Events (GRACE) risk score 2.0 [26] after acute coronary syndromes (ACS), and whether such an association could follow a nonlinear relationship with the hazards, as recently shown for HDL-cholesterol regarding incident overall mortality [27]. This evidence concerns the gene APOA1 and acute coronary syndrome.