PKM and cancer: With respect to the repertoire of glycolytic isoenzymes involved in the action of RSV, Iqbal et al. observed that RSV down-regulate pyruvate kinase 2 (PKM2) expression by inhibiting mTOR signaling and suppressed cancer metabolism, characterized by a decreased glucose uptake, lower lactate production (aerobic glycolysis), and reduced anabolism (macromolecule synthesis) in various cancer cell lines [140].