Therefore, the monoclonal antibodies, particularly antibody 6.6.1, blocked the integrin signaling pathway activation of FAK in colorectal cancer, of JNK and ERK kinases, in colorectal and pancreatic cancers, and of JNK, ERK, Src and AKT in melanoma and breast cancers (Figure 4 and Figure 5). This evidence concerns the gene MAPK8 and breast cancer.