It was recently reported that sestrin2 can suppress sepsis through induction of mitophagy and inhibition of NLR family pyrin domain-containing 3 (NLRP3) activation in macrophages; sestrin2 enhances the autophagic efficiency by recognizing and shipping the damaged mitochondria to lysosomes for degradation [52]. The gene discussed is NLRP3; the disease is Sepsis.