MAPT and Alzheimer disease: With HIV infection, the sestrin2 immunoreactivity pattern shifted from neuropil predominance (N) to neuropil and neuronal-soma co-dominance (NS) and neuronal-soma predominance (S); in AD brains, sestrin2 immunoreactivity was mostly intense in the neuropil and co-localized with phosphor-Tau immunoreactivity in a subset of neurofibrillary lesions [94].