These include amyloid-beta peptide (Aβ) and hyperphosphorylated tau protein in AD, Lewy body containing α-synuclein in PD, mutant huntingtin (Htt) in HD, TAR DNA-binding protein-43 (TDP-43) in amyotrophic lateral sclerosis (ALS), and others. The gene discussed is APP; the disease is amyotrophic lateral sclerosis.