This implies that they are important early events in the tumorigenesis of carcinosarcoma and thus could be targeted with PIK3CA/mTOR (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha /Mechanistic Target of Rapamycin Kinase) inhibitors [29,38]. This evidence concerns the gene PIK3CA and carcinosarcoma.