LDHA and cancer: The 1,4-dihydronicotinamide adenine dinucleotide (NADH)-dependent enzyme LDHA mediates a redox reaction for the reduction of pyruvate to lactate at the end of glycolysis when the cytosolic NADH/nicotinamide adenine dinucleotide (NAD+) ratio is high, which is a crucial step for regenerating NAD+, and is needed to maintain glycolysis for the survival of cancer cells [6,7,8].