In line with these results, we found that tumor-derived lactate up-regulated the expressions of Arg-1, CD206, VEGF, and YM1 genes in macrophages, and an MA-mediated decrease of tumor-derived lactate resulted in a reduction of Arg-1, CD206, VEGF, and YM1 mRNA levels in macrophages (Figure 5D). This evidence concerns the gene ARG1 and neoplasm.