MAP2K7 and Miyoshi myopathy: In addition to bevacizumab, other VEGFRs targeting compounds (including aflibercept-VEGF-trap), activated pathway inhibitors (tyrosine kinase, PI3K/Akt-MEK/ERK, FAK), anti-cytokine drugs, and monoclonal antibodies have shown an anti-angiogenic effect, but not sufficiently to enter in the clinical MM setting [65,66,67,68,69,70,71,72,73].