BCL2 and glioblastoma: Lastly, we proved that 5-AcTMF downregulated BCL-2 and BCL-xL in a STAT3-dependent manner (Figure 4), and that downregulation of BCL-2 or BCL-xL is required for 5-AcTMF to induce GBM cell apoptosis (Figure 5 and Figure 6).