STAT3 and brain neoplasm: In line with this, it is reasonable to speculate that 5-AcTMF, as an acetylated derivative of Tangeretin, is ostensibly BBB permeable, and hence, is accessible to the location of brain tumors such as GBM, where 5-AcTMF thwarts constitutive STAT3 activation in tumor cells to induce GBM cell apoptosis.