The 3p.21.31 region may harbor candidate tumor suppressor genes due to the frequent copy number loss in various cancer types [5,6,7], including HYAL2, TUSC2, RASSF1, ZMYND10, NPRL2, CYB561D2, TMEM115. and CACNA2D2 [8]. Here, RASSF1 is linked to cancer.