CREB1 and Rett syndrome: Moreover, MeCP2, a transcriptional regulator whose mutations cause Rett syndrome, was found abundant in a TRPC6 promoter region resulting a transcriptional regulator of this gene [50] TRPC6, in turn, activates neuronal pathways, including BDNF, CAMKIV, Akt, and CREB signaling pathways, also involved in ASDs [51].