The amino acid change in our study patient, SYTL4 R(279)C in exon 9 (Figure 1, Figure 3 and Figure 5), has been determined to severely affect the critical functioning of this gene’s encoded RAB protein binding region at its N-terminal [51,52], which is perhaps analogous to the effect of a significant change in Sytl4 gene expression observed among the altered protein networks in the mouse brain proteome in a mouse model of anxiety [12]. Here, SYTL4 is linked to Anxiety.