Another transmembrane protein gene family member, TMEM231, is a known syndromic autism gene: TMEM231 gene is associated with two neurological syndromes: Joubert syndrome-20 [MIM:614970] and Meckel syndrome 11 (https://gene.sfari.org/database/human-gene/; MIM:615397);. The gene discussed is TMEM231; the disease is Joubert syndrome with ocular defect.