GPHN and autism: Although the novel X-linked TMEM187 missense gene variant c.708G>T; p.Gln236His found in our high-functioning autism patient is not known as an ASD gene, but analysis of the latest STRING network interactions reveal direct interactions with four known ASD genes, namely HCFC1, TMLHE, MECP2, and GPHN (https://gene.sfari.org/database/human-gene/) (Figure 7).