INS and type 1 diabetes mellitus: Consequently, people affected by T1D strongly rely on exogenous insulin in order to maintain blood glucose (BG) levels within the safe range ([70, 180] mg/dL) [1] and avoid long-term complications, e.g., neuropathy, retinopathy, and micro/macro-vascular heart diseases, due to sustained hyperglycemia (BG > 180 mg/dL) [2].