Thus, learning the changes of PDGF concentrations in MDA-MB-231 cells gave insights on how the latter response to ampelopsin E. We believed ampelopsin E was able to reduce invasiveness of MDA-MB-231 cells through suppressing PDGF, which promotes EMT via activation of STAT3 or PI3K pathway [132] and are responsible for breast tumor aggressiveness through activation of Notch and NF-κB signaling [128,133]. Here, STAT3 is linked to breast neoplasm.