In summary, this study highlighted the inhibitory effects of ampelopsin E towards the invasiveness of MDA-MB-231 breast carcinoma cells by significantly suppressing migration, invasion, invadopodia formation, gelatin degradation and invasion/invadopodia-related protein expressions such as PDGF, MMP2, MMP9 and MMP14. This evidence concerns the gene MMP2 and breast carcinoma.