In particular, we examined the expression level of the cyclin-dependent kinase inhibitor 3 (CDKN3), Non-SMC Condensin II Complex Subunit G2 (NCAPG2), Ndc80 kinetochore complex component (NUF2) and High Mobility Group Box 1 (HMGB1) genes, which are involved either in cancer cell proliferation or in mediating DNA repair processes. This evidence concerns the gene HMGB1 and cancer.