Thus, our study may propose a speculative scenario that some splenic inflammatory monocytes differentiate into monocyte-derived F4/80-expressing CD3ε-B220-Gr-1-TER119-CD11c+MHC class II+ DCs during sepsis, although the role of the DC subset in modulating inflammatory progression remains to be elucidated in near future. The gene discussed is ITGAX; the disease is Sepsis.