As a consequence of the major role of PMCA in maintaining cytosolic calcium homeostasis in neurons [48,49,50,51], these results indicate that MB can act as a drug that affords protection against the neurotoxicity of the sustained rise of cytosolic calcium induced by Aβ and tau, thereby slowing down brain neurodegeneration induced by these major AD biomarkers. Here, MAPT is linked to Alzheimer disease.