Mechanistically, miR-206 is positively regulated by Yes-associated protein (YAP), a key molecule of the Hippo pathway, which induces cardiomyocytes apoptosis and hypertrophy, and targets the forkhead box P1 (FoxP1), known to negatively regulate cardiac hypertrophy through inhibition of Nfat3 [109]. The gene discussed is FOXP1; the disease is hypertrophy.