Previously, we found that HCHF-fed LDLR+/− hamsters with hypercholesterolemia and atherosclerotic lesions are more pronounced than the wild-type group, suggesting that severity of hypercholesterolemia and atherosclerosis may be modulated by diet intervention to achieve the experimental purpose of lipid disorder-related CHD. The gene discussed is LDLR; the disease is familial hypercholesterolemia.