RANKL does not drive tolerance to MAPK inhibition through pathway re‐activation as has commonly been observed (Lito et al., 2012; Smith et al., 2017; Straussman et al., 2012), but rather via an increase in MITF expression similar to the TNF‐α mediated increase in MITF that occurs when macrophages are co‐cultured with melanoma cells (Smith et al., 2014). The gene discussed is TNFSF11; the disease is melanoma.