In addition to the melanoma‐osteoblast interplay outlined in this study, RANKL signalling is important for lymphocyte differentiation and T‐cell activation; indeed inhibition of RANKL signalling has been shown to induce more anti‐tumour T‐cells in murine cancer models (Cheng & Fong, 2014; de Groot et al., 2018; Leibbrandt & Penninger, 2008). This evidence concerns the gene TNFSF11 and melanoma.