To next examine whether melanoma CM differentiated osteoblasts function in a similar way to PTH‐differentiated osteoblasts, we treated melanoma cells with the CM taken from osteoblasts that were differentiated with melanoma CM and we observed an increase in MITF expression (Figure 2b), as previously seen for CM taken from PTH‐differentiated osteoblasts (Figure 1d‐f). Here, PTH is linked to melanoma.