TNFRSF11A and melanoma: Indeed, co‐culture of A375 melanoma cells with osteoblasts inhibited the BRAFi‐induced cleavage of caspase 3 and counteracted the reduction in cell number, but the knockdown of RANK (RANK KD) was sufficient to re‐sensitize the co‐cultured melanoma cells to BRAFi (Figure 5c).