We did not explore significant effect modification of the association between adiponectin and composite renal outcome in different subgroups (Fig 2), including age, sex, eGFR, UPCR, albumin, BMI and presence of metabolic syndrome (P for interaction = 0.33, 0.87, 0.51, 0.32, 0.08, 0.30, and 0.59, respectively). This evidence concerns the gene ADIPOQ and metabolic syndrome.