Using the MDRD database, Menon et al. did not reveal a direct correlation between adiponectin and the risk of kidney failure among 820 patients with GFR ranging between 13 and 55 ml/min/1.73 m2 (mean GFR 33 ± 12 mL/min/1.73 m2)[21]. This evidence concerns the gene ADIPOQ and kidney failure.