As we all know, MCM genes are pivotal for DNA replication and cell cycle process.[7]Study showed that enhanced NF-κB expression as a prognostic predictor is positively correlated with poor survival outcome of NSCLC patients.[51]MCM4 may affect the prognosis of lung cancer via NF-κB pathway.[52] Aurora kinase B regulates cell mitosis by adjusting the chromosomal passenger complex. Here, MCM4 is linked to lung cancer.