Previous reports showed increased expression of MCM2 in colorectal cancer (CRC) tissues could be adopted as diagnostic biomarker.[28]The MCM3 immune-histochemical staining can be adopted as biomarker for oral squamous cell carcinoma early detection.[29] MCM4 has been opined to participate in the tumorigenesis of esophageal cancer.[30,31]Different cancers like pancreaticobiliary malignancy (PBC), [32,33]esophageal cancer [11]and cervical cancer (CC)[34] have been studied in the light of MCM5 as a diagnostic marker. The gene discussed is MCM4; the disease is esophageal cancer.