PTPN14 and cancer: Using these mutant proteins, we demonstrated the significance of the direct interaction of E7 of HPV18, one of the two major high-risk HPVs, with PTPN14, which is necessary for inducing degradation of this host antitumor protein (Figs 5 and 6A), up-regulating the cancer-associated Hippo signaling downstream effectors (Fig 7A–7C), and promoting cell proliferation, migration, and invasion (Figs 6C–6E and 7D–7F).