This leads to the release of proapoptotic factors from the mitochondrial intermembrane space into the cytosol.29 A recent study demonstrates that the extrinsic and intrinsic apoptotic pathways activate pannexin‐1 to drive NLRP3 inflammasome assembly, which is involved in the pathogenesis of viral hepatitis.30, 31. The gene discussed is NLRP3; the disease is viral hepatitis.