Genetic variants within the NOS2 gene have been associated with IBD susceptibility in different populations (Martín et al., 2007; Senhaji et al., 2017), and increased mRNA levels were found in the colonic mucosa of patients with active UC, compared to patients with inactive UC and controls, and in CD patients compared to controls (Coburn et al., 2016). The gene discussed is NOS2; the disease is inflammatory bowel disease.