NR3C1 and Insulin resistance: The analyses supported the MCA-based findings with statistically significant associations and average causal effects between cortisol suppression (glucocorticoid receptor sensitivity), high-sensitivity C-reactive protein (hs-CRP; inflammation), homeostatic model assessment of insulin resistance (HOMA-IR), γ-glutamyltransferase (GGT; oxidative stress), hypoxanthine (energy deficit and hypoxia), and several metabolites.