In terms of MODY and type 2 diabetes, the similarities include overlap in the age of onset and negativity for antibodies, and treatment generally does not require long-term insulin; however, differences are also notable, more adolescent patients with type 2 diabetes with obesity have metabolic syndrome, and insulin function is mainly caused by insulin resistance; by contrast, patients with MODY are generally not obese and have no metabolic syndrome, and islet function defects are mainly caused by insulin secretion defects. This evidence concerns the gene INS and obesity disorder.