HACE1 and Anxiety: Hace1 KO mice generated in our group previously are generally healthy, viable, and fertile.2 First, we found no significant differences in anxiety levels in Hace1 WT and KO littermates analyzed by the OFT and the elevated plus maze (figure e-3, A and B, links.lww.com/NXG/A150); however, we noted a reduction in the distance traveled during the testing (figure 3A).