Interestingly, patients with HPV-negative HNSCC whose tumors contain alterations in the NSD1 gene (n = 60), showed significantly improved overall (p = 0.006) and disease-free (p = 0.007) survival compared to patients with tumors that harbor wild-type NSD1 (n = 397) (Fig. 5A). The gene discussed is NSD1; the disease is head and neck squamous cell carcinoma.