NSD1 and head and neck squamous cell carcinoma: Using isogenic cell lines, our data showed that even partial downregulation of NSD1 (25–50%, Figs. 8 and 11) sensitized HPV(−) HNSCC cells and immortalized keratinocytes to cisplatin and carboplatin (Fig. 9), which may, at least in part, explain the survival advantage of NSD1 mutations in HPV(−) HNSCC (Fig. 5 A).