CFTR and cystic fibrosis: Of note, in CF patients bearing class II CFTR mutations, treatment with epigallocatechin-gallate (EGCG, an inhibitor of the autophagy-inhibitory acetyl transferase EP300) [21] can prolong the beneficial effects of cysteamine with respect to autophagy induction and restore CFTR function in nasal respiratory epithelial cells [18, 19].