NGB and early-onset autosomal dominant Alzheimer disease: Alzheimer's disease research on mNgb-Tg-1 x APP (Sw, Ind) (amyloid precursor protein) double transgenic mice showed that increased Ngb levels reduce amyloid beta (Aβ) deposits, decrease levels of Aβ(1-40) and Aβ(1-42), and improve behavioural performance, thereby abating the Alzheimer's disease phenotype ([46], Figure 4).