As many studies focus on the role of Ngb in neural-derived tissues in vivo, Ngb overexpression was mainly assessed on a plethora of equivalent neural-like cell lines in vitro: primary cortical neurons [55, 102], SH-SY5Y and N2a neuroblastoma cells [51, 55, 103–106], HN33 mouse hippocampal neuronal cells x neuroblastoma cells [107, 108], PC12 pheochromocytoma cells [52], human H4 neuroglioma cells [109], human U87 and U251 glioblastoma cells [110], and mouse HT22 hippocampal neuronal cells [58] (Figure 2). The gene discussed is NGB; the disease is glioblastoma.